Although surgery was the standard treatment for early gastrointestinal cancers, endoscopic
resection is now a standard treatment for early gastrointestinal cancers without regional …

Esophageal squamous cell carcinoma (ESCC) is among the most deadly forms of human
malignancy characterized by late stage diagnosis, metastasis, therapy resistance and …

Background Trifluridine/tipiracil showed activity and was well tolerated in a phase 2 study of
pretreated patients with advanced gastric cancer done in Japan. We investigated whether …

Esophageal cancer has a poor prognosis and high mortality rate, with an estimated 16,910
new cases and 15,910 deaths projected in 2016 in the United States. Squamous cell …

Purpose: The current management of advanced esophageal squamous cell carcinoma
(ESCC) remains unsatisfactory. We investigated the safety, efficacy, and biomarkers of SHR …

Esophageal cancer (EC) is an aggressive malignancy with an increasing incidence and a
poor prognosis. EC is histologically divided into two major categories: adenocarcinoma …

Background Fusobacterium nucleatum (F. nucleatum) is a gut microbe implicated in
gastrointestinal tumorigenesis. Predicting the chemotherapeutic response is critical to …

Background Immune checkpoint inhibitors combined with chemotherapy as a neoadjuvant
therapy have been applied to the treatment of esophageal squamous cell carcinoma …

Introduction Up to 32% of patients with esophageal cancer show a pathological complete
response (ypCR) after neoadjuvant therapy. To prevent overtreatment, the indication to …

Approximately half of the patients diagnosed with oesophageal cancer present with
unresectable or metastatic disease. Treatment for these patients aims to control dysphagia …