Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications
Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying
pathobiology of COVID-19 will support the design of rational treatments targeting the life …
pathobiology of COVID-19 will support the design of rational treatments targeting the life …
Cognitive impact of COVID-19: looking beyond the short term
COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …
Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
Within the brain: the renin angiotensin system
LD Jackson, W Eldahshan, SC Fagan… - International journal of …, 2018 - mdpi.com
For many years, modulators of the renin angiotensin system (RAS) have been trusted by
clinicians for the control of essential hypertension. It was recently demonstrated that these …
clinicians for the control of essential hypertension. It was recently demonstrated that these …
Inflammogenesis of secondary spinal cord injury
MA Anwar, TS Al Shehabi, AH Eid - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Spinal cord injury (SCI) and spinal infarction lead to neurological complications and
eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major …
eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major …
[HTML][HTML] Expression profiling meta-analysis of ACE2 and TMPRSS2, the putative anti-inflammatory receptor and priming protease of SARS-CoV-2 in human cells, and …
Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and has resulted in hundreds of thousands of …
syndrome coronavirus 2 (SARS-CoV-2) and has resulted in hundreds of thousands of …
ACE2 in brain physiology and pathophysiology: evidence from transgenic animal models
N Alenina, M Bader - Neurochemical research, 2019 - Springer
Abstract Angiotensin-converting enzyme 2 (ACE2) is a protein consisting of two domains,
the N-terminus is a carboxypeptidase homologous to ACE and the C-terminus is …
the N-terminus is a carboxypeptidase homologous to ACE and the C-terminus is …
Coronavirus disease 2019 and stroke: clinical manifestations and pathophysiological insights
Abstract Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is a global health threat. Some COVID-19 patients …
syndrome coronavirus 2 (SARS-CoV-2), is a global health threat. Some COVID-19 patients …
Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: Past, present and future
F Gouveia, A Camins, M Ettcheto, J Bicker… - Ageing Research …, 2022 - Elsevier
Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …
A review on the neurological manifestations of COVID-19 infection: a mechanistic view
There is increasing evidence of neurological manifestations and complications in patients
with coronavirus disease 19 (COVID-19). More than one-quarter of patients with COVID-19 …
with coronavirus disease 19 (COVID-19). More than one-quarter of patients with COVID-19 …