Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA),
Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via …

Cutaneous melanoma is a highly immunogenic malignancy that is surgically curable at early
stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high …

Endothelial to mesenchymal transition (EndMT) plays a major role during development, and
also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells …

Epithelial-mesenchymal transition (EMT) is a critical process in the development of many
tissues and organs in multicellular organisms that its important role in the pathogenesis of …

Melanoma has markedly increased worldwide during the past several decades in the
Caucasian population and is responsible for 80% of skin cancer deaths. Considering that …

Epithelial-Mesenchymal Transition (EMT) is a critical process in embryonic development in
which epithelial cells undergo a transdifferentiation into mesenchymal cells. This process is …

The five genes of the lysyl oxidase family encode enzymes that covalently cross-link
components of the extracellular matrix, such as various types of collagen and elastin, and …

Multidrug resistance (MDR) is an issue that is not only related to cancer cells but also
associated with the tumor microenvironments. MDR involves the complicated cancer cellular …

Disruption of the endothelial barrier by tumour-derived secreted factors is a critical step in
cancer cell extravasation and metastasis. Here, by comparative proteomic analysis of …