Andrographis paniculata has long been part of the traditional herbal medicine system in
Asia and in Scandinavia. Andrographolide was isolated as a major bioactive constituent of …

Purpose: Michael receptor molecules derived from plants are biologically active due to
electrophilic groups in their structure. They can target nucleophilic residues on disease …

Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by 2019 novel
coronavirus (2019-nCoV) has been a crisis of global health, whereas the effective vaccines …

Natural and traditional medicines, being a great source of drugs and drug leads, have
regained wide interests due to the limited success of high-throughput screening of …

Abstract Cyclooxygenase-2 (COX-2) is the key enzyme responsible for the conversion of
arachidonic acid to prostaglandins that display pro-inflammatory properties and thus, it is a …

The search for new anti-inflammatory agents is challenging due to the complexity of the
inflammatory process and its role in host defense. Over the past few decades, a significant …

Protein-protein interactions (PPIs) are central to a variety of biological processes, and their
dysfunction is implicated in the pathogenesis of a range of human diseases, including …

Background Bone marrow mesenchymal stem cell (BMSCs) therapy is an important cell
transplantation strategy in the regenerative medicine field. However, a severely ischemic …

Andrographolide from leaves of Andrographis paniculata has been known to possess
various bioactivities. In the present study, we aimed to explore the neuroprotection of …

Metabolic disorder is a major characteristic of cancer cells, and controlling genes involved in
metabolic shifts can be an effective strategy for cancer treatment. Andrographolide (AG), a …