Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily
around the time of activation of the adaptive immune response. Here, we provide evidence …

The cellular landscape of the human intestinal tract is dynamic throughout life, developing in
utero and changing in response to functional requirements and environmental exposures …

Despite over a century of research, Mycobacterium tuberculosis (Mtb), the causative agent of
tuberculosis (TB), continues to kill 1.5 million people annually. Though less than 10% of …

The immune response to antigens is a key aspect of immunology, as it provides
opportunities for therapeutic intervention. However, the induction of immunological tolerance …

For yet unknown reasons, severely ill COVID-19 patients often become critically ill around
the time of activation of adaptive immunity. Here, we show that anti-Spike IgG from serum of …

Chronic upper airway inflammation is amongst the most prevalent chronic disease entities in
the Western world with prevalence around 30%(rhinitis) and 11%(rhinosinusitis). Chronic …

Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common sinonasal
inflammatory disorder with high heterogeneity. Increasing evidence have indicated that the …

IgG Abs are crucial for various immune functions, including neutralization, phagocytosis, and
Ab-dependent cellular cytotoxicity. In this study, we identified another function of IgG by …

Macrophages play a key role in induction of inflammatory responses. These inflammatory
responses are mostly considered to be instigated by activation of pattern recognition …

Human bronchial epithelial (HBE) cells play an essential role during bacterial infections of
the airways by sensing pathogens and orchestrating protective immune responses. We here …