It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

Degradation of extracellular matrix is crucial for malignant tumour growth, invasion,
metastasis and angiogenesis. Matrix metalloproteinases (MMPs) are a family of zinc …

The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes, whose
physiological functions include tissue remodelling and embryogenesis. The importance of …

Despite much information on their catalytic properties and gene regulation, we actually know
very little of what matrix metalloproteinases (MMPs) do in tissues. The catalytic activity of …

This randomised, double-blind, placebo-controlled study was designed to evaluate the
ability of the orally administered matrix metalloproteinase inhibitor, marimastat, to prolong …

The five years survival rate for patients with gastric cancer is 15–25%. With the aim of
improving survival, chemotherapy has been used in different adjuvant settings. Similarly, but …

Objectives: We sought to determine whether matrix metalloproteinase (MMP) inhibitor, PG-
116800, reduced left ventricular (LV) remodeling after myocardial infarction (MI) …

Collagen turnover is a slow process on a biologic timescale with at 1 2 of 20–27 days that is
mediated primarily by the matrix metalloproteinases (MMPs). Low collagen metabolism is …

At least 56 matrix metalloproteinase (MMP) inhibitors have been pursued as clinical
candidates since the late 1970's when the first drug discovery program targeting this enzyme …