Applications of single-cell sequencing in cancer research: progress and perspectives
Y Lei, R Tang, J Xu, W Wang, B Zhang, J Liu… - Journal of hematology & …, 2021 - Springer
Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …
Application of artificial intelligence technology in oncology: Towards the establishment of precision medicine
Simple Summary Artificial intelligence (AI) technology has been advancing rapidly in recent
years and is being implemented in society. The medical field is no exception, and the clinical …
years and is being implemented in society. The medical field is no exception, and the clinical …
Single-cell analyses highlight the proinflammatory contribution of C1q-high monocytes to Behçet's disease
W Zheng, X Wang, J Liu, X Yu, L Li… - Proceedings of the …, 2022 - National Acad Sciences
Behçet's disease (BD) is a chronic vasculitis characterized by systemic immune aberrations.
However, a comprehensive understanding of immune disturbances in BD and how they …
However, a comprehensive understanding of immune disturbances in BD and how they …
Chromatin accessibility profiling methods
L Minnoye, GK Marinov, T Krausgruber, L Pan… - Nature Reviews …, 2021 - nature.com
Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …
Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade
Therapeutic options for autoimmune diseases typically consist of broad and targeted
immunosuppressive agents. However, sustained clinical benefit is rarely achieved, as the …
immunosuppressive agents. However, sustained clinical benefit is rarely achieved, as the …
[HTML][HTML] Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis
Background Although ample knowledge exists about phenotype and function of cutaneous T
lymphocytes, much less is known about the lymphocytic components of the skin's innate …
lymphocytes, much less is known about the lymphocytic components of the skin's innate …
[HTML][HTML] Immunogenomic landscape of hematological malignancies
Understanding factors that shape the immune landscape across hematological
malignancies is essential for immunotherapy development. We integrated over 8,000 …
malignancies is essential for immunotherapy development. We integrated over 8,000 …
Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia
T cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder of
mature, clonally expanded T cells, where somatic-activating STAT3 mutations are common …
mature, clonally expanded T cells, where somatic-activating STAT3 mutations are common …
Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation
J Huuhtanen, S Adnan-Awad, J Theodoropoulos… - Leukemia, 2024 - nature.com
Immunological control of residual leukemia cells is thought to occur in patients with chronic
myeloid leukemia (CML) that maintain treatment-free remission (TFR) following tyrosine …
myeloid leukemia (CML) that maintain treatment-free remission (TFR) following tyrosine …
Trends and potential of machine learning and deep learning in drug study at single-cell level
Cancer treatments always face challenging problems, particularly drug resistance due to
tumor cell heterogeneity. The existing datasets include the relationship between gene …
tumor cell heterogeneity. The existing datasets include the relationship between gene …