[HTML][HTML] Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine–DNA methyltransferase in hematopoietic cells
A Schambach, J Bohne, S Chandra, E Will… - Molecular Therapy, 2006 - cell.com
Severe adverse events related to insertional mutagenesis have reinforced interest in self-
inactivating (SIN) retroviral vectors lacking enhancer–promoter sequences in the long …
inactivating (SIN) retroviral vectors lacking enhancer–promoter sequences in the long …
Lomeguatrib, a Potent Inhibitor of O6-Alkylguanine-DNA-Alkyltransferase: Phase I Safety, Pharmacodynamic, and Pharmacokinetic Trial and Evaluation in …
M Ranson, MR Middleton, J Bridgewater, SM Lee… - Clinical cancer …, 2006 - AACR
Purpose: A major mechanism of resistance to temozolomide involves the DNA repair protein
O 6-alkylguanine-DNA-alkyltransferase (ATase). The main aims of this phase I trial were to …
O 6-alkylguanine-DNA-alkyltransferase (ATase). The main aims of this phase I trial were to …
[HTML][HTML] Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI
D Chinnasamy, MD Milsom, J Shaffer, J Neuenfeldt… - Virology Journal, 2006 - Springer
Background A number of gene therapy applications would benefit from vectors capable of
expressing multiple genes. In this study we explored the feasibility and efficiency of …
expressing multiple genes. In this study we explored the feasibility and efficiency of …
Triazene compounds in the treatment of acute myeloid leukemia: a short review and a case report
L Bonmassar, F Marchesi, E Pascale… - Current medicinal …, 2013 - ingentaconnect.com
Acute myeloid leukemia (AML) is a highly lethal disease, especially in old patients.
Chemoresistance and the absence of host immune responses against autochthonous …
Chemoresistance and the absence of host immune responses against autochthonous …
Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O6-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the …
Human exposure to DNA alkylating agents is poorly characterized, partly because only a
limited range of specific alkyl DNA adducts have been quantified. The human DNA repair …
limited range of specific alkyl DNA adducts have been quantified. The human DNA repair …
[HTML][HTML] A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer
OA Khan, M Ranson, M Michael, I Olver… - British journal of …, 2008 - nature.com
To evaluate the tumour response to lomeguatrib and temozolomide (TMZ) administered for 5
consecutive days every 4 weeks in patients with metastatic colorectal carcinoma. Patients …
consecutive days every 4 weeks in patients with metastatic colorectal carcinoma. Patients …
The effect of O 6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1, 3-bis (2-chloroethyl …
R Pepponi, G Marra, MP Fuggetta, S Falcinelli… - … of Pharmacology and …, 2003 - ASPET
The prognosis of advanced melanoma is generally poor, because this tumor commonly
exhibits intrinsic or acquired resistance to chemotherapy. In an attempt to identify the …
exhibits intrinsic or acquired resistance to chemotherapy. In an attempt to identify the …
Poly(ADP‐ribose) polymerase inhibitor increases growth inhibition and reduces G2/M cell accumulation induced by temozolomide in malignant glioma cells
Temozolomide (TZM) is a novel methylating agent currently under investigation for treatment
of recurrent high‐grade gliomas. Although TZM generates a wide spectrum of methyl …
of recurrent high‐grade gliomas. Although TZM generates a wide spectrum of methyl …
[HTML][HTML] O6-(4-bromothenyl) guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts
Tumour resistance to chemotherapy involving methylating agents such as DTIC
(dacarbazine) and temozolomide is linked to expression of the DNA repair protein O 6 …
(dacarbazine) and temozolomide is linked to expression of the DNA repair protein O 6 …
Attenuation of O 6-methylguanine-DNA methyltransferase activity and mRNA levels by cisplatin and temozolomide in Jurkat cells
S D'Atri, G Graziani, PM Lacal, V Nisticò… - … of Pharmacology and …, 2000 - ASPET
The DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) is important in
cellular resistance to certain alkylating antitumor agents such as the methylating drug …
cellular resistance to certain alkylating antitumor agents such as the methylating drug …