Our limited understanding of metabolic aging poses major challenges to comprehending the
diverse cellular alterations that contribute to age-related decline, and to devising targeted …

Non-alcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic
steatohepatitis (NASH) have emerged as the leading causes of chronic liver disease-related …

Key points Time‐restricted feeding (TRF, in which energy intake is restricted to 8 h/day
during the dark phase) alone or combined with aerobic exercise (AE) training can prevent …

Purpose Endoplasmic reticulum (ER) stress is implicated in the development of type 2
diabetes mellitus (T2DM) and insulin resistance. Tribbles homolog 3 (TRB3) is a …

Taste is one of our five primary senses, along with smell, sight, hearing, and touch. The
ability to taste is of utmost importance to our well-being and survival; tasting has historically …

Metabolism plays an important role in regulating aging at several levels, and metabolic
reprogramming is the main driving force of aging. Due to the different metabolic needs of …

Despite intensive studies for decades, the common mechanistic correlations among the
underlying pathology of diabetes mellitus (DM), its complications, and effective clinical …

Significance: During aging, excessive production of reactive species in the liver leads to
redox imbalance with consequent oxidative damage and impaired organ homeostasis …

Senile animals exhibit a high risk of elevated endoplasmic reticulum (ER) stress, attenuated
circadian clock, and impaired steroidogenesis in testes. However, how these three …

Amelioration of hypercholesterolemia is essential for the treatment of atherosclerotic
cardiovascular disease. Sodium sulphate is the effective component of mirabilite, which has …