Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat
chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of …

Rationale Depression has the topmost prevalence of all psychiatric diseases. It is
characterized by a high recurrence rate, disability, and numerous and mostly unclear …

Depression and anxiety disorders are debilitating diseases resulting in substantial economic
costs to society. Traditional antidepressants often take weeks to months to positively affect …

Amitifadine, the only drug ever clinically tested in Phase 3 for treating depression, is a triple
reuptake inhibitor (TRI) that simultaneously interacts with human monoamine transporters …

Selective serotonin reuptake inhibitors are clinically prescribed antidepressants that act by
increasing the local concentrations of neurotransmitters at synapses and in extracellular …

Receptors of leptin, the prototypical adipokine, are expressed throughout the cortex and
several other areas of the brain. Although typically studied for its role in energy intake and …

Monoamine transporters (MATs) regulate neurotransmission via the reuptake of dopamine,
serotonin and norepinephrine from extra-neuronal regions and thus maintain …

Gabapentinoids (gabapentin and pregabalin) and antidepressants (tricyclic antidepressants
and serotonin noradrenaline reuptake inhibitors) are often used to treat chronic pain. The …

While the neurochemistry that underpins the behavioral phenotypes of depression is the
subject of many studies, oxidative stress caused by the inflammation comorbid with …

Antidepressants selectively inhibiting serotonin reuptake (SSRIs) represent a highly effective
drug class, and novel therapeutic strategies were proposed to improve SSRIs' drug efficacy …