1. Background: the concept of 'endothelial dysfunc- deficiency of either the substrate for the
enzyme NO tion' synthase or one of its critical co-factors. Alterations of endothelial cell …

Genetics ultimately defines an individual, yet the phenotype of an adult is extensively
determined by the sequence of lifelong exposures, termed the exposome. The redox theory …

Oxidative stress is caused by an imbalance between reactive oxygen species (ROS)
production and the ability of an organism to eliminate these toxic intermediates. Mutations in …

Background Glutathione (GSH) deficiency is common in HIV‐infected individuals and is
associated with impaired T cell function and impaired survival. N‐acetylcysteine (NAC) is …

Increasing evidence suggests that oxidative and nitrosative stress play an important role in
regulation of cardiac myocyte growth and survival. The cardiovascular system is …

After myocardial infarction (MI), the heart undergoes extensive myocardial remodeling
through the accumulation of fibrous tissue in both the infarcted and noninfarcted …

Objective: To study the mitochondrial respiratory chain enzyme activities in patients with
idiopathic dilated cardiomyopathy (IDC). Methods: Mitochondrial respiratory chain enzyme …

The molecular and pharmacological manipulation of the endogenous redox system is a
promising therapy to limit myocardial damage after a heart attack; however, antioxidant …

Oxidative stress is caused by an imbalance between the production of reactive oxygen
species (ROS) and the ability of an organism to eliminate these toxic intermediates …

There is extensive experimental evidence from in vitro and animal experiments that
congestive heart failure (CHF) is a state of oxidative stress. Moreover, in animal models, the …