Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …

Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have
been the focus of numerous investigations over the past two decades. APP is the precursor …

The β‐amyloid precursor protein (APP) has been extensively studied for its role as the
precursor of the β‐amyloid protein (Aβ) of Alzheimer's disease. However, the normal …

The amyloid precursor protein (APP) plays a central role in the pathophysiology of
Alzheimer's disease in large part due to the sequential proteolytic cleavages that result in …

Biochemical and genetic evidence establishes a central role of the amyloid precursor
protein (APP) in Alzheimer disease (AD) pathogenesis. Biochemically, deposition of the β …

The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD)
pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited …

The Drosophila larval neuromuscular system is relatively simple, containing only 32 motor
neurons in each abdominal hemisegment, and its neuromuscular junctions (NMJs) have …

Interest in the amyloid precursor protein (APP) has increased in recent years due to its
involvement in Alzheimer's disease. Since its molecular cloning, significant genetic and …

Proteolytic processing of the amyloid‐β precursor protein (APP) generates the Aβ amyloid
peptide of Alzheimer's disease. The biological function of APP itself remains, however …

A critical role of the amyloid precursor protein (APP) in Alzheimer's disease (AD)
pathogenesis has been well established. However, the physiological function of APP …