Amyloid precursor protein processing and Alzheimer's disease
RJ O'brien, PC Wong - Annual review of neuroscience, 2011 - annualreviews.org
Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …
Amyloid precursor protein trafficking, processing, and function
G Thinakaran, EH Koo - Journal of Biological Chemistry, 2008 - ASBMB
Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have
been the focus of numerous investigations over the past two decades. APP is the precursor …
been the focus of numerous investigations over the past two decades. APP is the precursor …
Insights into the physiological function of the β‐amyloid precursor protein: beyond Alzheimer's disease
E Dawkins, DH Small - Journal of neurochemistry, 2014 - Wiley Online Library
The β‐amyloid precursor protein (APP) has been extensively studied for its role as the
precursor of the β‐amyloid protein (Aβ) of Alzheimer's disease. However, the normal …
precursor of the β‐amyloid protein (Aβ) of Alzheimer's disease. However, the normal …
Biology and pathophysiology of the amyloid precursor protein
H Zheng, EH Koo - Molecular neurodegeneration, 2011 - Springer
The amyloid precursor protein (APP) plays a central role in the pathophysiology of
Alzheimer's disease in large part due to the sequential proteolytic cleavages that result in …
Alzheimer's disease in large part due to the sequential proteolytic cleavages that result in …
Physiological functions of APP family proteins
UC Müller, H Zheng - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Biochemical and genetic evidence establishes a central role of the amyloid precursor
protein (APP) in Alzheimer disease (AD) pathogenesis. Biochemically, deposition of the β …
protein (APP) in Alzheimer disease (AD) pathogenesis. Biochemically, deposition of the β …
The amyloid precursor protein: beyond amyloid
H Zheng, EH Koo - Molecular neurodegeneration, 2006 - Springer
The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD)
pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited …
pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited …
Development and plasticity of the Drosophila larval neuromuscular junction
KP Menon, RA Carrillo, K Zinn - Wiley Interdisciplinary Reviews …, 2013 - Wiley Online Library
The Drosophila larval neuromuscular system is relatively simple, containing only 32 motor
neurons in each abdominal hemisegment, and its neuromuscular junctions (NMJs) have …
neurons in each abdominal hemisegment, and its neuromuscular junctions (NMJs) have …
Amyloid precursor protein and neural development
M Nicolas, BA Hassan - Development, 2014 - journals.biologists.com
Interest in the amyloid precursor protein (APP) has increased in recent years due to its
involvement in Alzheimer's disease. Since its molecular cloning, significant genetic and …
involvement in Alzheimer's disease. Since its molecular cloning, significant genetic and …
The amyloid‐β precursor protein: integrating structure with biological function
C Reinhard, SS Hébert, B De Strooper - The EMBO journal, 2005 - embopress.org
Proteolytic processing of the amyloid‐β precursor protein (APP) generates the Aβ amyloid
peptide of Alzheimer's disease. The biological function of APP itself remains, however …
peptide of Alzheimer's disease. The biological function of APP itself remains, however …
Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis
A critical role of the amyloid precursor protein (APP) in Alzheimer's disease (AD)
pathogenesis has been well established. However, the physiological function of APP …
pathogenesis has been well established. However, the physiological function of APP …