Fungi and bacteria encounter each other in various niches of the human body. There, they
interact directly with one another or indirectly via the host response. In both cases …

Sepsis is a serious medical condition characterized by dysregulated systemic inflammatory
responses followed by immunosuppression. To study the pathophysiology of sepsis, diverse …

Sepsis is a common clinical entity causing thousands of deaths and costing billions of
healthcare dollars annually in the US alone [1–4]. Further, sepsis and septic shock represent …

Background The lack of a reliable scoring system that predicts the development of septic
shock and death precludes comparison of disease and/or treatment outcomes in animal …

Background Sepsis involves life-threatening organ dysfunction and is caused by a
dysregulated host response to infection. No specific therapies against sepsis have been …

Sepsis is a state of disrupted inflammatory homeostasis that is often initiated by infection.
The development and progression of sepsis is multi-factorial, and affects the cardiovascular …

The model of cecal ligation and puncture (CLP) in rodents has been used extensively to
investigate the clinical settings of sepsis and septic shock. This model produces a …

Sepsis and trauma are both leading causes of death in the United States and represent
major public health challenges. Murine models have largely been used in sepsis and …

A clinically important adverse drug reaction, heparin-induced thrombocytopenia (HIT), is
induced by antibodies specific for complexes of the chemokine platelet factor 4 (PF4) and …

Objective: To postulate reasons as to why the benefits seen with novel therapies in animal
models of sepsis fail to translate to the clinical setting. Data Source: MEDLINE searches and …