Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

Peptide molecule has high bioactivity, good biocompatibility, and excellent biodegradability.
In addition, it has adjustable amino acid structure and sequence, which can be flexible …

The design of bioactive supramolecular chirality is always hampered by the lack of feasible
schemes to assigned specific biological activities. Herein, we developed a “mirror-image …

Background Although anti-programmed cell death protein 1 (PD-1) immunotherapy is
greatly effective in melanoma treatment, low response rate and treatment resistance …

Clinical treatment of chronic wounds, particularly those prone to relapse, has been
hampered by the regeneration, infection complications, and malignant transformation of …

Introduction Chirality is immanent in nature, and chiral molecules can achieve their
pharmacological action through chiral matching with biomolecules and molecular …

Chirality in biomolecules is ubiquitous in our world, but oral nanomedicines constructed from
chiral peptides are extremely rare, principally because of the immature nanofabrication and …

Despite recent advances in treatment, overall survival rates for metastatic melanoma,
especially those that invade the lungs, continue to be low, with 5-year survival rates of only …

Critical challenges remain in trauma emergency and surgical procedures involving liver
bleeding, particularly in perforating wounds that cannot be pressed and large wounds that …

Clinical translation of therapeutic peptides, particularly those targeting intracellular protein–
protein interactions (PPIs), has been hampered by their inefficacious cellular internalization …