Timing of primary maternal cytomegalovirus infection and rates of vertical transmission and fetal consequences

C Chatzakis, Y Ville, G Makrydimas, K Dinas… - American journal of …, 2020 - Elsevier
Objective Cytomegalovirus infection is the most frequent congenital infection and a major
cause of long-term neurologic morbidity. The aim of this meta-analysis was to calculate the …

Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention

MCJ Cheeran, JR Lokensgard… - Clinical microbiology …, 2009 - Am Soc Microbiol
Congenital cytomegalovirus (CMV) infection is the leading infectious cause of mental
retardation and hearing loss in the developed world. In recent years, there has been an …

Cytomegalovirus latency and reactivation: recent insights into an age old problem

L Dupont, MB Reeves - Reviews in medical virology, 2016 - Wiley Online Library
Human cytomegalovirus (HCMV) infection remains a major cause of morbidity in patient
populations. In certain clinical settings, it is the reactivation of the pre‐existing latent infection …

Molecular determinants and the regulation of human cytomegalovirus latency and reactivation

D Collins-McMillen, J Buehler, M Peppenelli… - Viruses, 2018 - mdpi.com
Human cytomegalovirus (HCMV) is a beta herpesvirus that establishes a life-long
persistence in the host, like all herpesviruses, by way of a latent infection. During latency …

Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management

D Devakumar, A Bamford, MU Ferreira… - The Lancet infectious …, 2018 - thelancet.com
Microcephaly is an important sign of neurological malformation and a predictor of future
disability. The 2015–16 outbreak of Zika virus and congenital Zika infection brought the …

EZH2-Myc driven glioblastoma elicited by cytomegalovirus infection of human astrocytes

R El Baba, S Pasquereau, S Haidar Ahmad, F Monnien… - Oncogene, 2023 - nature.com
Mounting evidence is identifying human cytomegalovirus (HCMV) as a potential oncogenic
virus. HCMV has been detected in malignant gliomas. EZH2 and Myc play a potential …

Consequences of viral infection and cytokine production during pregnancy on brain development in offspring

D Elgueta, P Murgas, E Riquelme, G Yang… - Frontiers in …, 2022 - frontiersin.org
Infections during pregnancy can seriously damage fetal neurodevelopment by aberrantly
activating the maternal immune system, directly impacting fetal neural cells. Increasing …

Cytomegalovirus and HIV: a dangerous pas de deux

S Gianella, S Letendre - The Journal of infectious diseases, 2016 - academic.oup.com
Human immunodeficiency virus (HIV)–infected adults who take stable antiretroviral therapy
(ART) are at risk for early onset of age-related diseases. This is likely due to a complex …

Is HCMV a tumor promoter?

L Soroceanu, CS Cobbs - Virus research, 2011 - Elsevier
Human cytomegalovirus (HCMV) is a beta-herpesvirus that causes persistent infection in
humans and can cause severe disease in fetuses and immunocompromised individuals …

Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target

N Baryawno, A Rahbar… - The Journal of …, 2011 - Am Soc Clin Investig
Medulloblastomas are the most common malignant brain tumors in children. They express
high levels of COX-2 and produce PGE2, which stimulates tumor cell proliferation. Human …