Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …

Long intergenic non-coding RNAs (lincRNAs) are defined as RNA transcripts that are longer
than 200 nucleotides. By definition, these RNAs must not have open reading frames that …

Tobacco smoke exposure contributes to the global burden of communicable and chronic
diseases. To identify the immune cells affected by smoking, we use single-cell RNA …

Background Despite remarkable progress, the immunotherapies currently used in the clinic,
such as immune checkpoint blockade (ICB) therapy, still have limited efficacy against many …

IL-7 receptor signaling is essential for the generation and maintenance of conventional T
cells. Immunosuppressive Foxp3+ Treg cells, however, express uniquely low amounts of the …

Interleukin-7 is a non-redundant growth, differentiation and survival factor for human T
lymphocytes. Most circulating, mature T cells express the receptor for IL-7, but not all …

Abstract GFI1 and GFI1B are small nuclear proteins of 45 and 37 kDa, respectively, that
have a simple two-domain structure: The first consists of a group of six c-terminal C 2 H 2 …

Almost like a living being in and of itself, tumors actively interact with and modify their
environment to escape immune responses. Owing to the pre-formation of cancer-favorable …

Glucocorticoids are widely used for therapy of hematologic malignancies. Unfortunately,
chronic treatment with glucocorticoids commonly leads to adverse effects including skin and …

Glucocorticoids (GC) are renowned for their pleiotropic effects in all organ systems, their
ubiquitous use in numerous clinical settings, and the abundant adverse effects they may …