Triazole analogues as potential pharmacological agents: A brief review
Background A large number of studies have recently reported that, because of their
significant biological and pharmacological properties, heterocyclic compounds and their …
significant biological and pharmacological properties, heterocyclic compounds and their …
Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
Design, synthesis, and antimicrobial activities of 1, 2, 3-triazole glycoside clickamers
Bacterial resistance remains a significant threat and a leading cause of death worldwide,
despite massive attempts to control infections. In an effort to develop biologically active …
despite massive attempts to control infections. In an effort to develop biologically active …
Novel promising benzoxazole/benzothiazole‐derived immunomodulatory agents: Design, synthesis, anticancer evaluation, and in silico ADMET analysis
Eleven novel benzoxazole/benzothiazole‐based thalidomide analogs were designed and
synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized …
synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized …
1, 2, 3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies
A new series of triazole-thiazole hybrids were designed, synthesized by the Multi-
component reaction approach and evaluated in vitro antimicrobial activity. Most of the tested …
component reaction approach and evaluated in vitro antimicrobial activity. Most of the tested …
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase
ED AlFadly, PA Elzahhar, A Tramarin, S Elkazaz… - European journal of …, 2019 - Elsevier
Neuroinflammation and cholinergic deficit are key detrimental processes involved in
Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the …
Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the …
Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study
G Moussa, R Alaaeddine, LM Alaeddine… - European journal of …, 2018 - Elsevier
Click chemistry was used to synthesize a new series of thioquinazolinone molecules
equipped with propargyl moiety, 1, 2, 3-triazolyl and isoxazolyl rings. Our design was based …
equipped with propargyl moiety, 1, 2, 3-triazolyl and isoxazolyl rings. Our design was based …
[PDF][PDF] 1, 2, 3-Triazoles: scaffold with medicinal significance
The medicinal chemists have considered the synthesis of 1, 2, 3-triazole based heterocycles
as the corner stone of medicinal chemistry due to their important biological activities. This …
as the corner stone of medicinal chemistry due to their important biological activities. This …
Synthesis, computational quantum chemical study, in silico ADMET and molecular docking analysis, in vitro biological evaluation of a novel sulfur heterocyclic …
S Murugavel, C Ravikumar, G Jaabil… - … Biology and Chemistry, 2019 - Elsevier
Computational quantum chemical study and biological evaluation of a synthesized novel
sulfur heterocyclic thiophene derivative containing 1, 2, 3-triazole and pyridine moieties …
sulfur heterocyclic thiophene derivative containing 1, 2, 3-triazole and pyridine moieties …
Catalytic Oxidative Carbonylation of Amino Moieties to Ureas, Oxamides, 2‐Oxazolidinones, and Benzoxazolones
The direct syntheses of ureas, oxamides, 2‐oxazolidinones, and benzoxazolones by the
oxidative carbonylation of amines, β‐amino alcohols, and 2‐aminophenols allows us to …
oxidative carbonylation of amines, β‐amino alcohols, and 2‐aminophenols allows us to …