Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …

Frontotemporal dementia (FTD) is a neurodegenerative disease of growing interest, since it
accounts for up to 10% of middle-age-onset dementias and entails a social, economic, and …

Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the
brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of …

Hydrogels are useful drug release systems and tissue engineering scaffolds. However,
synthetic hydrogels often require harsh gelation conditions and can contain toxic by …

Loss of function (LoF) of TAR-DNA binding protein 43 (TDP-43) and mis-localization,
together with TDP-43-positive and hyperphosphorylated inclusions, are found in post …

Motoric cognitive risk syndrome (MCR) is defined by the presence of slow gait and
subjective cognitive decline. It is well recognized as a prodrome for dementia, but the …

An extracellular network of molecular chaperones protects a diverse array of proteins that
reside in or pass through extracellular spaces. Proteins in the extracellular milieu face …

An increasing body of experimental evidence implicates a relationship between
immunometabolic deterioration and the progression of Parkinson's disease (PD) with a …

The cellular redox state is essential for inhibiting ferroptosis. Progranulin (PGRN) plays an
important role in maintaining the cellular redox state after ischemic brain injury. However …