The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and
progression are being increasingly defined. The TRACERx Renal studies and others that …

Germline loss-of-function mutations of the VHL tumor suppressor gene cause von Hippel–
Lindau disease, which is associated with an increased risk of hemangioblastomas, clear cell …

Mutational inactivation of VHL is the earliest genetic event in the majority of clear cell renal
cell carcinomas (ccRCC), leading to accumulation of the HIF-1α and HIF-2α transcription …

Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …

Dysregulation of autophagy in diabetic kidney disease (DKD) has been reported, but the
underlying mechanism and its pathogenic role remain elusive. We show that autophagy was …

Abstract Since the Von Hippel–Lindau (VHL) disease tumour suppressor gene VHL was
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …

Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is
characterized by elevated glycogen levels and fat deposition. These consistent metabolic …

Myelin sheaths provide critical functional and trophic support for axons in white matter tracts
of the brain. Oligodendrocyte precursor cells (OPCs) have extraordinary metabolic …

More than 2% of adults harbor a pancreatic cyst, a subset of which progresses to invasive
lesions with lethal consequences. To assess the genomic landscapes of neoplastic cysts of …

The Krebs cycle enzyme fumarate hydratase (FH) is a human tumor suppressor whose
inactivation is associated with the development of leiomyomata, renal cysts, and tumors. It …