[HTML][HTML] Hesperidin and hesperetin against heavy metal toxicity: Insight on the molecular mechanism of mitigation

AC Famurewa, K Renu, MA Eladl… - Biomedicine & …, 2022 - Elsevier
Toxic heavy metals (THMs) are non-essential hazardous environmental pollutants with
intractable health challenges in humans and animals. Exposure to lead (Pb), cadmium (Cd) …

[HTML][HTML] The role and mechanism of flavonoid herbal natural products in ulcerative colitis

JC Xue, S Yuan, H Meng, XT Hou, J Li… - Biomedicine & …, 2023 - Elsevier
Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine that presents
clinically with abdominal pain, mucopurulent stools, and posterior urgency. The lesions of …

Anti-inflammation activity of flavones and their structure–activity relationship

X Wang, Y Cao, S Chen, J Lin, J Bian… - Journal of Agricultural …, 2021 - ACS Publications
Flavones are an important class of bioactive constituents in foods, and their structural
diversity enables them to interact with different targets. In particular, flavones are known for …

Attenuation of sodium arsenite-induced cardiotoxicity and neurotoxicity with the antioxidant, anti-inflammatory, and antiapoptotic effects of hesperidin

M Kuzu, FM Kandemir, S Yıldırım, C Çağlayan… - … Science and Pollution …, 2021 - Springer
In the scope of the study, the protective effect of hesperidin (HES), a flavanone glycoside,
was investigated against sodium arsenite (NaAsO 2, SA) induced heart and brain toxicity …

Natural products modulate cell apoptosis: A promising way for the treatment of ulcerative colitis

C Liu, Y Zeng, Y Wen, X Huang, Y Liu - Frontiers in pharmacology, 2022 - frontiersin.org
Ulcerative colitis (UC) is a chronic inflammatory bowel disease impacting patients' quality of
life and imposing heavy societal and economic burdens. Apoptosis of intestinal epithelial …

Protective effects of 6-gingerol on cardiotoxicity induced by arsenic trioxide through AMPK/SIRT1/PGC-1α signaling pathway

X Han, Y Yang, M Zhang, X Chu, B Zheng… - Frontiers in …, 2022 - frontiersin.org
Background and Objective: Arsenic trioxide (As2O3) induced cardiotoxicity to limit the
clinical applications of the effective anticancer agent. 6-Gingerol (6G) is the main active …

Comprehensive analysis of endoplasmic reticulum stress-associated genes signature of ulcerative colitis

B Deng, F Liao, Y Liu, P He, S Wei, C Liu… - Frontiers in …, 2023 - frontiersin.org
Background Endoplasmic reticulum stress (ERS) is a critical factor in the development of
ulcerative colitis (UC); however, the underlying molecular mechanisms remain unclear. This …

Cinnamaldehyde and hesperetin attenuate TNBS‐induced ulcerative colitis in rats through modulation of the JAk2/STAT3/SOCS3 pathway

MG Elhennawy, EA Abdelaleem… - … of biochemical and …, 2021 - Wiley Online Library
Ulcerative colitis is an autoimmune inflammatory disorder with a negative impact on the life
quality of patients. Cinnamaldehyde and hesperetin were chosen due to their antioxidants …

Uncovering the shared molecule and mechanism between ulcerative colitis and atherosclerosis: an integrative genomic analysis

J Huang, F Wang, X Tang - Frontiers in Immunology, 2023 - frontiersin.org
Background Ulcerative colitis (UC) and atherosclerosis (AS) are closely related. However,
the pathologic mechanisms underlying the co-occurrence of UC and AS are not well …

Potential of natural flavonols and flavanones in the treatment of ulcerative colitis

C Li, Y Tang, Y Ye, M Zuo, Q Lu - Frontiers in Pharmacology, 2023 - frontiersin.org
Ulcerative colitis (UC) is an inflammatory bowel disease generally characterized by chronic,
persistent, recurrent, and non-specific ulcers of the intestine. Its main clinical manifestations …