Abstract Purpose of Review To present a comprehensive overview regarding criteria,
epidemiology, and controversies that have arisen in the literature about the existence and …

Mitochondria play a key role in maintaining energy homeostasis in metabolic tissues,
including adipose tissues. The two main types of adipose tissues are the white adipose …

Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

Skeletal muscle possesses dramatic metabolic plasticity that allows for the rapid adaptation
in cellular energy transduction to meet the demands of the organism. Obesity elicits changes …

Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …

Recently, several studies have examined whether low‐volume sprint interval training (SIT)
may improve aerobic and metabolic function. The objective of this study was to …

Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease
worldwide, and is associated with increased morbidity and mortality in patients with both …

Mitochondrial dysfunction is a characteristic trait of human and rodent obesity, insulin
resistance and fatty liver disease. Here we show that high-fat diet (HFD) feeding causes …

Insulin resistance condition is associated to the development of several syndromes, such as
obesity, type 2 diabetes mellitus and metabolic syndrome. Although the factors linking …

Abstract Sirtuin 1 (S IRT1), the mammalian homolog of SIR2, was originally identified as a
NAD-dependent histone deacetylase, the activity of which is closely associated with lifespan …