RING finger domain and RING finger-like ubiquitin ligases (E3s), such as U-box proteins,
constitute the vast majority of known E3s. RING-type E3s function together with ubiquitin …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

Ubiquitin-dependent signaling during the DNA damage response (DDR) to double-strand
breaks (DSBs) is initiated by two E3 ligases, RNF8 and RNF168, targeting histone H2A and …

The opposing activities of 53BP1 and BRCA1 influence pathway choice in DNA double-
strand-break repair. How BRCA1 counteracts the inhibitory effect of 53BP1 on DNA …

The maintenance of genome integrity is essential for any organism survival and for the
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …

TRIM E3 ubiquitin ligases regulate a wide variety of cellular processes and are particularly
important during innate immune signalling events. They are characterized by a conserved …

Ubiquitylation, the covalent modification of proteins by the addition of ubiquitin, relies on a
cascade of enzymes that culminates in an E3 ligase that promotes the transfer of ubiquitin …

The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and
chemotherapy-induced DNA crosslinks, and responds to replication stress,. Genetic …

MAGEA4 is a cancer-testis antigen primarily expressed in the testes but aberrantly
overexpressed in several cancers. MAGEA4 interacts with the RING ubiquitin ligase RAD18 …

Replicative polymerases (pols) cannot accommodate damaged template bases, and these
pols stall when such offenses are encountered during S phase. Rather than repairing the …