Therapeutic implications for sphingolipid metabolism in metabolic dysfunction-associated steatohepatitis

B Ramos-Molina, J Rossell… - Frontiers in …, 2024 - frontiersin.org
The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), a
leading cause of chronic liver disease, has increased worldwide along with the epidemics of …

Harnessing Oxylipins and Inflammation Modulation for Prevention and Treatment of Colorectal Cancer

J Gretschel, R El Hage, R Wang, Y Chen… - International Journal of …, 2024 - mdpi.com
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide, ranking as the
third most malignant. The incidence of CRC has been increasing with time, and it is reported …

Lipidomics characterization of the microbiome in people with diabetic foot infection using MALDI-TOF MS

J Walczak-Skierska, F Monedeiro, E Maślak… - Analytical …, 2023 - ACS Publications
Lipidomic profiling has emerged as a powerful tool for the comprehensive characterization
of bacterial species, particularly in the context of clinical diagnostics. Utilizing matrix-assisted …

Lipidomics profiling of Metformin-induced changes in obesity and type 2 diabetes mellitus: insights and biomarker potential

M Mujammami, SM Aleidi, AZ Buzatto, A Alshahrani… - Pharmaceuticals, 2023 - mdpi.com
Metformin is the first-line oral medication for treating type 2 diabetes mellitus (T2DM). In the
current study, an untargeted lipidomic analytical approach was used to investigate the …

Metformin increases 3-hydroxy medium chain fatty acids in patients with type 2 diabetes: a cross-sectional pharmacometabolomic study

K Naja, N Anwardeen, AM Malki… - Frontiers in …, 2024 - frontiersin.org
Background Metformin is a drug with a long history of providing benefits in diabetes
management and beyond. The mechanisms of action of metformin are complex, and …

Clusters of adipose tissue dysfunction in adults with type 2 diabetes identify those with worse lipidomic profile despite similar glycaemic control

G Della Pepa, F Carli, S Sabatini… - Diabetes/Metabolism …, 2024 - Wiley Online Library
Aims To investigate clusters of adipose tissue dysfunction, that is, with adipose tissue insulin
resistance (ADIPO‐IR) and large waist circumference (WC), identify a worse lipidomic profile …

Metabolomics in diabetes mellitus: clinical insight

SM Aleidi, H Al Fahmawi, A Masood… - Expert Review of …, 2023 - Taylor & Francis
ABSTRACT Introduction Diabetes Mellitus (DM) is a chronic heterogeneous metabolic
disorder characterized by hyperglycemia due to the destruction of insulin-producing …

Metabolomic profile of patients on levothyroxine treatment for hypothyroidism

H Benabdelkamel, MA Jaber… - European Thyroid …, 2023 - etj.bioscientifica.com
Background Hypothyroidism is clinically characterized by a decrease in levels of the
circulating thyroid hormones namely thyroxine and triiodothyronine. The main treatment for …

Metformin Can Decrease Serum levels of 12 (S)-Hydroxyeicosatetraenoic Acid in Adults with Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Y Li, L Dong, H Huang, Y Zhou, Q Yin, X Wu, Z Du… - 2024 - researchsquare.com
Background: Type 2 diabetes mellitus (T2DM) often accompanies by diabetic kidney
disease (DKD). The occurrence and progression of T2DM and DKD are closely related to …