Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Dystrophin is a 427 kDa sub-membrane cytoskeletal protein, associated with the inner
surface membrane and incorporated in a large macromolecular complex of proteins, the …

Aggregation of acetylcholine receptors (AChRs) on skeletal muscle fibers is thought to be
mediated by the basal lamina protein agrln. Structural similarities shared by agrin and …

Duchenne muscular dystrophy is the most prevalent and severe form of human muscular
dystrophy. Investigations into the molecular basis for Duchenne muscular dystrophy were …

DUCHENNE muscular dystrophy (DMD) is a severe, progressive muscle-wasting disease
that causes cardiac or respiratory failure1, 2 and results in death at about 20 years of age …

We used expression profiling to define the pathophysiological cascades involved in the
progression of two muscular dystrophies with known primary biochemical defects …

Many neuromuscular conditions are characterized by an exaggerated exercise-induced
fatigue response that is disproportionate to activity level. This fatigue is not necessarily …

Limb-girdle muscular dystrophy type 2D (LGMD 2D) is an autosomal recessive disorder
caused by mutations in the α-sarcoglycan gene. To determine how α-sarcoglycan deficiency …

Voltage-dependent Ca 2+ channels are modulated by complex interactions with the α 2 δ
subunit. In vitro translation was used to demonstrate a single transmembrane topology of the …

Dystrophin, the product of the Duchenne muscular dystrophy gene, is tightly associated with
the sarcolemmal membrane to a large glycoprotein complex. One function of the dystrophin …