Purpose The present review aims to emphasize that malignant gliomas are characterized by
the diffuse invasion of distant brain tissue by a myriad of single migrating cells that exhibit …

The combined and ordered sequential action of glycosidases and glycosyltransferases in
mammalian cell compartments leads to the addition of defined glycans to proteins and lipids …

pH-responsive biodegradable micelles were prepared from block copolymers comprising of
a novel acid-labile polycarbonate hydrophobe and poly (ethylene glycol)(PEG). Two new …

The major structural component of the cell wall in Mycobacterium tuberculosis, infection by
which causes tuberculosis, is the mycolyl-arabinogalactan (mAG) complex. This large …

A series of fatty acid ester and ether derivatives have been chemically synthesised based on
carbohydrate and non-carbohydrate polyhydroxylated scaffolds. The synthesised …

Cimetidine (CIM), the prototypical histamine H2 receptor antagonist (H2RA), was brought to
market based on its ability to accelerate healing of gastrointestinal ulcers through the …

Amphiphilicity is one of the desirable features in the process of drug development which
improves the biological as well as the pharmacokinetics profile of bioactive molecule …

Treated glioblastoma patients survive from 6 to 14 months. In the first part of this review, we
describe glioma origins, cancer stem cells and the genomic alterations that generate …

The efficient synthesis of structurally diverse, multivalent, heterogeneous
neoglycoconjugates by means of a series of different click‐based strategies is described …

Object. Malignant gliomas consist of both heterogeneous proliferating and migrating cell
subpopulations, with migrating glioma cells exhibiting less sensitivity to antiproliferative or …