Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

Deficits in cognitive control, a core disturbance of schizophrenia, appear to emerge from
impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory …

Sensory processing deficits, first investigated by Kraepelin and Bleuler as possible
pathophysiological mechanisms in schizophrenia, are now being recharacterized in the …

Abstract The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale study of child
development that combines neuroimaging, diverse clinical and cognitive phenotypes, and …

Objective: The Penn Computerized Neurocognitive Battery (CNB) was designed to measure
performance accuracy and speed on specific neurobehavioral domains using tests that were …

The adult form of attention deficit/hyperactivity disorder (aADHD) has a prevalence of up to
5% and is the most severe long-term outcome of this common neurodevelopmental disorder …

Objective Developing categorical diagnoses that have biological meaning within the clinical
phenotype of psychosis (schizophrenia, schizoaffective disorder, and bipolar I disorder with …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

There is substantial evidence for partial overlap of genetic influences on schizophrenia and
bipolar disorder, with family, twin, and adoption studies showing a genetic correlation …