Mechanisms of action of fluvoxamine for COVID-19: a historical review

Y Hashimoto, T Suzuki, K Hashimoto - Molecular psychiatry, 2022 - nature.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of …

Maternal immune activation by poly I: C as a preclinical model for neurodevelopmental disorders: a focus on autism and schizophrenia

FL Haddad, SV Patel, S Schmid - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
Maternal immune activation (MIA) in response to a viral infection during early and mid-
gestation has been linked through various epidemiological studies to a higher risk for the …

[HTML][HTML] Brain changes in a maternal immune activation model of neurodevelopmental brain disorders

L Bergdolt, A Dunaevsky - Progress in neurobiology, 2019 - Elsevier
The developing brain is sensitive to a variety of insults. Epidemiological studies have
identified prenatal exposure to infection as a risk factor for a range of neurological disorders …

Oxidative stress and the pathophysiology and symptom profile of schizophrenia spectrum disorders

AJ Murray, JC Rogers, MZUH Katshu, PF Liddle… - Frontiers in …, 2021 - frontiersin.org
Schizophrenia is associated with increased levels of oxidative stress, as reflected by an
increase in the concentrations of damaging reactive species and a reduction in anti-oxidant …

Arketamine for cognitive impairment in psychiatric disorders

K Hashimoto - European Archives of Psychiatry and Clinical …, 2023 - Springer
Cognitive impairment has been observed in patients with various psychiatric disorders,
including schizophrenia, major depressive disorder (MDD), and bipolar disorder (BD) …

[HTML][HTML] Essential role of Keap1-Nrf2 signaling in mood disorders: overview and future perspective

K Hashimoto - Frontiers in pharmacology, 2018 - frontiersin.org
Depression is one of the most common mood disorders with a high rate of relapse.
Accumulating evidence suggests that the transcription factor Kelch-like erythroid cell-derived …

The potential use of l-sulforaphane for the treatment of chronic inflammatory diseases: A review of the clinical evidence

N Mazarakis, K Snibson, PV Licciardi, TC Karagiannis - Clinical nutrition, 2020 - Elsevier
Summary According to the World Health Organisation, 70% of all deaths globally can be
attributed to chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel …

[HTML][HTML] Early identification and intervention of schizophrenia: insight from hypotheses of glutamate dysfunction and oxidative stress

CH Lin, HY Lane - Frontiers in psychiatry, 2019 - frontiersin.org
Schizophrenia is a severe mental disorder which leads to functional deterioration. Early
detection and intervention are vital for better prognosis. However, the diagnosis of …

[HTML][HTML] Translational opportunities in the prenatal immune environment: Promises and limitations of the maternal immune activation model

MD Bauman, J Van de Water - Neurobiology of disease, 2020 - Elsevier
The prenatal environment, and in particular, the maternal-fetal immune environment, has
emerged as a targeted area of research for central nervous system (CNS) diseases with …

[HTML][HTML] Long-lasting beneficial effects of maternal intake of sulforaphane glucosinolate on gut microbiota in adult offspring

Y Wei, L Chang, G Liu, X Wang, Y Yang… - The Journal of Nutritional …, 2022 - Elsevier
Mounting evidence suggests the impact of maternal diet on the health of offspring. We
reported that maternal diet of sulforaphane glucosinolate (SGS) could prevent behavioral …