Background Cancer immunotherapy has changed the standard of care for a subgroup of
patients with advanced disease. Immune checkpoint blockade (ICB) in particular has shown …

The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Chemotherapy is ubiquitous in first-line treatment of advanced gastric cancer, yet responses
are heterogeneous, and little is known about mediators of chemotherapy response. To move …

Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent
death that did not trigger an immune response, in recent years a new concept of …

PURPOSE To determine the predictive and prognostic value of the consensus molecular
subtypes (CMSs) of colorectal cancer (CRC) that represent a merging of gene expression …

Despite curative-intent treatment, most patients with locally advanced esophageal cancer
will experience disease recurrence or locoregional progression, highlighting the need for …

Intercellular communication between tumor cells, immune cells and the stroma characterises
the tumor microenvironment, which is instrumental for establishing the ecological niche that …

Recently, cytokine-based pro-tumourigenic signalling has been found to play a major role in
the immune system's pro-tumourigenic activity. On the other hand, other recent findings have …

Immune checkpoint inhibitors (ICIs) have transformed the treatment paradigm for several
malignancies. While the use of single-agent or combined ICIs has achieved acceptable …

Purpose: FOLFIRINOX has demonstrated promising results for patients with pancreatic
ductal adenocarcinoma (PDAC). Chemotherapy-induced immunogenic cell death can prime …