RNA therapeutics (eg siRNA, oligonucleotides, mRNA, etc.) show great potential for the
treatment of a myriad of diseases. However, to reach their site of action in the cytosol or …

RNA interference with the ability to specifically silence target genes has shown great
potential to treat various diseases. The primary challenge for RNA interference is to …

Background: Exosomes, as natural intercellular information carriers, have great potential in
the field of drug delivery. Many studies have focused on modifying exosome surface proteins …

Quinine is a promising building block for creating polymer carriers for intracellular nucleic
acid delivery. This is due to its ability to bind to genetic material through intercalation and …

Hydroxychloroquine (HCQ) is a unique class of medications that has been widely utilized for
the treatment of cancer. HCQ plays a dichotomous role by inhibiting autophagy induced by …

Quinine is a promising natural product building block for polymer-based nucleic acid
delivery vehicles as its structure enables DNA binding through both intercalation and …

Polymeric vehicles that efficiently package and controllably release nucleic acids enable the
development of safer and more efficacious strategies in genetic and polynucleotide …

Simple Summary Gene therapy is one of the most promising approaches to treating various
inherited and acquired diseases by delivering genetic constructs into the cells and tissues of …

Nucleic acid delivery with cationic polymers is a promising alternative to expensive viral-
based methods; however, it often suffers from a lower performance. Herein, we present a …

Cholangiocarcinoma (CCA) is the second most common primary liver malignancy with
extremely poor therapeutic outcome due to high drug resistance, widespread metastasis …