Plant phenolics: Bioavailability as a key determinant of their potential health-promoting applications

P Cosme, AB Rodríguez, J Espino, M Garrido - Antioxidants, 2020 - mdpi.com
Phenolic compounds are secondary metabolites widely spread throughout the plant
kingdom that can be categorized as flavonoids and non-flavonoids. Interest in phenolic …

Benefits and implications of resveratrol supplementation on microbiota modulations: a systematic review of the literature

AD Inchingolo, G Malcangi, AM Inchingolo… - International Journal of …, 2022 - mdpi.com
Resveratrol is a polyphenol that has been shown to possess many applications in different
fields of medicine. This systematic review has drawn attention to the axis between …

Occurrence, bioavailability, anti-inflammatory, and anticancer effects of pterostilbene

WS Lin, JV Leland, CT Ho, MH Pan - Journal of agricultural and …, 2020 - ACS Publications
Supplementation with natural compounds found in fruits and vegetables has long been
associated with a reduced risk of several types of cancer. Pterostilbene is a natural …

Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR

MA Meshram, UO Bhise, PN Makhal, VR Kaki - European Journal of …, 2021 - Elsevier
Inflammation is a most complex pathological process that gives birth to different diseases.
Different inflammatory mediators are released during an inflammation responsible for acute …

In vivo formed metabolites of polyphenols and their biological efficacy

G Serreli, M Deiana - Food & function, 2019 - pubs.rsc.org
It is well known that plant-derived polyphenols are biologically relevant for human health
both for their direct antioxidant activity and for their effects in the modulation of intracellular …

Network Pharmacology Integrated Molecular Docking and Dynamics to Elucidate Saffron Compounds Targeting Human COX-2 Protein

A Ali, AB Wani, BA Malla, J Poyya, NJ Dar, F Ali… - Medicina, 2023 - mdpi.com
Background and Objectives: Cyclooxygenase-2 (COX-2) is mostly linked to inflammation
and has been validated as a molecular target for treating inflammatory diseases. The …

[HTML][HTML] Piceatannol, a comprehensive review of health perspectives and pharmacological aspects

HI Al-Jaber, AK Shakya, MA Al-Qudah… - Arabian Journal of …, 2024 - Elsevier
Piceatannol, a natural polyphenolic stilbenoid found in numerous fruits and vegetables such
as grapes, passionate fruit, blueberries, and white tea, is well recognized for its diverse …

The anti‐obesity and anti‐inflammatory capabilities of pterostilbene and its colonic metabolite pinostilbene protect against tight junction disruption from western diet …

YC Koh, SJ Lin, K Nagabhushanam… - Molecular Nutrition & …, 2022 - Wiley Online Library
Scope Tight junctions (TJs) are a member of the intestinal epithelium barrier that provides
the first line of protection against external factors. Anti‐obesity and protective effects of …

The therapeutic potential of urolithin A for cancer treatment and prevention

VS Rogovskii - Current cancer drug targets, 2022 - ingentaconnect.com
Background: Urolithin A is the metabolite of natural polyphenol ellagic acid and
ellagitannins generated by gut microbiota. Urolithin A is better absorbed in the …

Piceatannol and 3′-hydroxypterostilbene alleviate inflammatory bowel disease by maintaining intestinal epithelial integrity and regulating gut microbiota in mice

WS Lin, TL Chueh, K Nagabhushanam… - Journal of agricultural …, 2023 - ACS Publications
Inflammatory bowel disease has become a significant health concern across the globe,
causing frequent and long-term harm to the digestive system. This study evaluated the effect …