The spatial organization of chromosomes influences many nuclear processes including
gene expression. The cohesin complex shapes the 3D genome by looping together CTCF …

Roses have high cultural and economic importance as ornamental plants and in the
perfume industry. We report the rose whole-genome sequencing and assembly and …

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent
kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing …

In mammalian cells, the MYC oncoprotein binds to thousands of promoters,,,. During
mitogenic stimulation of primary lymphocytes, MYC promotes an increase in the expression …

Background Understanding the relationship between the millions of functional DNA
elements and their protein regulators, and how they work in conjunction to manifest diverse …

Adult stem cells occur in niches that balance self-renewal with lineage selection and
progression during tissue homeostasis. Following injury, culture or transplantation, stem …

The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function
together to shape chromatin architecture in mammalian cells, but the molecular details of …

Background Transcription regulation in pluripotent embryonic stem (ES) cells is a complex
process that involves multitude of regulatory layers, one of which is post-translational …

Th17 cells have critical roles in mucosal defense and are major contributors to inflammatory
disease. Their differentiation requires the nuclear hormone receptor RORγt working with …

DNA topoisomerase II inhibitors are a major class of cancer chemotherapeutics, which are
thought to eliminate cancer cells by inducing DNA double-strand breaks. Here we identify a …