Embryonic development in mammals is distinct from that in other vertebrates because it
depends on a small number of imprinted genes that are specifically expressed from either …

Dosage compensation for X-linked genes in mammals is accomplished by inactivating one
of the two X chromosomes in females. X-chromosome inactivation (XCI) occurs during …

Murine embryos that inherit a nonfunctional insulin-like growth factor-II/cation-independent
mannose 6-phosphate receptor (Igf2r) gene from their fathers are viable and develop …

Simplex optimization has generated several media that have improved the development of
mouse preimplantation embryos in vitro. One objective of this study was to compare the …

Genomic reprogramming of primordial germ cells (PGCs), which includes genome‐wide
demethylation, prevents aberrant epigenetic modifications from being transmitted to …

Specific mRNA degradation mediated by double-stranded RNA (dsRNA), which is termed
RNA interference (RNAi), is a useful tool with which to study gene function in several …

THE receptor for insulin-like growth factor type 2, also known as the cation-independent
mannose-6-phosphate receptor (Igf2/Mpr), is a multifunctional receptor thought to play a role …

Melatonin is a multifunctional molecule that mediates several circadian and seasonal
processes in animal reproduction. Melatonin and its metabolites are antioxidants and free …

Imprinting, the differential expression of the two alleles of a gene based on their parental
origin, requires that the alleles be distinguished or marked. A candidate for the differentiating …

Loss of imprinting (LOI), commonly observed in human tumors, refers to loss of monoallelic
gene regulation normally conferred by parent-of-origin-specific DNA methylation. To test the …