The pedunculopontine nucleus and Parkinson's disease
PA Pahapill, AM Lozano - Brain, 2000 - academic.oup.com
Akinesia and gait disturbances are particularly incapacitating for patients with Parkinson's
disease. The anatomical and physiological substrates for these disturbances are poorly …
disease. The anatomical and physiological substrates for these disturbances are poorly …
Topographical organization of the pedunculopontine nucleus
C Martinez-Gonzalez, JP Bolam… - Frontiers in …, 2011 - frontiersin.org
Neurons in the pedunculopontine nucleus (PPN) exhibit a wide heterogeneity in terms of
their neurochemical nature, their discharge properties, and their connectivity. Such …
their neurochemical nature, their discharge properties, and their connectivity. Such …
Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease
Gait disturbances and akinesia are extremely disabling in advanced Parkinson's disease. It
has been suggested that modulation of the activity of the pedunculopontine nucleus (PPN) …
has been suggested that modulation of the activity of the pedunculopontine nucleus (PPN) …
Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson's disease
The peduncolopontine nucleus modulates locomotor activity and dysfunction in this nucleus
may be responsible for the gait and postural impairments seen in Parkinson's disease and …
may be responsible for the gait and postural impairments seen in Parkinson's disease and …
Parallel basal ganglia circuits for voluntary and automatic behaviour to reach rewards
HF Kim, O Hikosaka - Brain, 2015 - academic.oup.com
The basal ganglia control body movements, value processing and decision-making. Many
studies have shown that the inputs and outputs of each basal ganglia structure are …
studies have shown that the inputs and outputs of each basal ganglia structure are …
The pedunculopontine nucleus
E Garcia-Rill - Progress in neurobiology, 1991 - Elsevier
In an effort to account for a large number of reported functions mediated by a small portion of
the midbrain, a hypothesis is advanced as a basis for discussion and not as established fact …
the midbrain, a hypothesis is advanced as a basis for discussion and not as established fact …
Comparison of MPTP-induced changes in spontaneous neuronal discharge in the internal pallidal segment and in the substantia nigra pars reticulata in primates
The basal ganglia are currently viewed as components of segregated corticosubcortical
reentrant circuits. One of these circuits, the” motor” circuit, is critically involved in the …
reentrant circuits. One of these circuits, the” motor” circuit, is critically involved in the …
The multifunctional mesencephalic locomotor region
D Ryczko, R Dubuc - Current pharmaceutical design, 2013 - ingentaconnect.com
In 1966, Shik, Severin and Orlovskii discovered that electrical stimulation of a region at the
junction between the midbrain and hindbrain elicited controlled walking and running in the …
junction between the midbrain and hindbrain elicited controlled walking and running in the …
Calcium, bioenergetics, and Parkinson's disease
E Zampese, DJ Surmeier - Cells, 2020 - mdpi.com
Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for
the core motor deficits of Parkinson's disease (PD). These neurons are autonomous …
the core motor deficits of Parkinson's disease (PD). These neurons are autonomous …
Glutamatergic inputs from the pedunculopontine nucleus to midbrain dopaminergic neurons in primates: Phaseolus vulgaris‐leucoagglutinin anterograde labeling …
To verify the possibility that the pedunculopontine nucleus is a source of glutamatergic
terminals in contact with midbrain dopaminergic neurons in the squirrel monkey, we used …
terminals in contact with midbrain dopaminergic neurons in the squirrel monkey, we used …