Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

BACKGROUND The escalating crisis of multidrug resistance is raising fears of untreatable
infections caused by bacterial “superbugs.” However, many patients already suffer from …

Persisters are transiently antibiotic-tolerant cells that complicate the treatment of bacterial
infections. Both theory and experiments have suggested that persisters facilitate genetic …

Anticancer therapies have been limited by the emergence of mutations and other
adaptations. In bacteria, antibiotics activate the SOS response, which mobilizes error-prone …

All bacteria form persisters, cells that are multidrug tolerant and therefore able to survive
antibiotic treatment. Due to the low frequencies of persisters in growing bacterial cultures …

Emerging evidence indicates that cancer is primarily a metabolic disease involving
disturbances in energy production through respiration and fermentation. The genomic …

Bacteria can rapidly and reversibly respond to changing environments via complex
transcriptional and post-transcriptional regulatory mechanisms. Many of these adaptations …

Microbial drug persistence is a widespread phenomenon in which a subpopulation of
microorganisms is able to survive antimicrobial treatment without acquiring resistance …

Antibiotic resistance is often the result of mutations that block drug activity; however, bacteria
also evade antibiotics by transiently expressing genes such as multidrug efflux pumps. A …

Bacteria display an abundance of cellular forms and can change shape during their life
cycle. Many plausible models regarding the functional significance of cell morphology have …