Medicinal plants produce valuable secondary metabolites with anticancer, analgesic,
anticholinergic or other activities, but low metabolite levels and limited available tissue …

Plants are a rich source of bioactive compounds, many of which have been exploited for
cosmetic, nutritional, and medicinal purposes. Through the characterization of metabolic …

Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza
pumila is an ideal plant model for the study of camptothecin production, with various …

Tanshinones are health-promoting diterpenoids found in Salvia miltiorrhiza and have wide
applications. Here, SmGGPPS (geranylgeranyl diphosphate synthase) and SmDXSII (1 …

Alkaloid-derived pharmaceuticals are commonly semisynthesized from plant-extracted
starting materials, which often limits their availability and final price. Recent advances in …

Introduction The development and application of novel therapeutic medicines for the
treatment of cancer are of vital importance to improve the disease< apos;> s outcome and …

The limited bioavailability of plant-derived natural products with anticancer activity poses
major challenges to the pharmaceutical industry. An example of this is camptothecin, a …

The plant kingdom is a rich source of bioactive compounds, many of which have been used
since pre-history for their therapeutic properties to treat a range of illnesses. These …

Cancer is probably the deadliest human disease in recent years. In the past few years, rapid
clinical progress has been made in the field of anticancer drug development. Plant …

Abstract Camptothecin (CPT), a well-known natural anti-cancer drug, is produced from
woody plant Camptotheca acuminata. Up to now, two CPT-derivatives, irinotecan and …