Cyclic AMP (cAMP) is an important intracellular signalling mediator. It is generated in
mammals by nine membrane-bound and one soluble adenylyl cyclases (ACs), each with …

Male factor accounts for about 30–50% of infertility. A common cause of male infertility is
drug abuse; either illicit or prolonged use of prescribed drugs. This study provides a review …

Background Hormonal methods for safe, reliable, and reversible contraception based on the
suppression of spermatogenesis could soon become available. We have investigated the …

Despite significant advances in contraceptive options for women over the last 50 yr, world
population continues to grow rapidly. Scientists and activists alike point to the devastating …

Drug delivery systems, capable of offering the flexibility of maintaining pharmacologically
effective therapeutic drug levels for extended periods of time while also allowing “dosing-on …

Here we investigated a pharmacological approach to inhibit spermatogenesis in the mouse
model by manipulating retinoid signaling using low doses of the pan-retinoic acid receptor …

Sperm of humans, non-human primates, and other mammalian subjects is considered to be
antigenic. The effect of changes in autoimmunity on reproductive cells such as spermatozoa …

In multicellular organisms, cell-cell interactions are mediated in part by cell junctions, which
underlie tissue architecture. Throughout spermatogenesis, for instance, preleptotene …

Context: Male hormonal contraceptive methods require effective suppression of sperm
output. Objective: The objective of the study was to define the covariables that influence the …

Adjudin is a derivative of 1H-indazole-3-carboxylic acid that was shown to have potent anti-
spermatogenic activity in rats, rabbits, and dogs. It exerts its effects most notably locally in …