Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Multicellularity has emerged multiple times in evolution, enabling groups of cells to share a
living space and reducing the burden of solitary tasks. While unicellular organisms exhibit …

Long ignored as a vestigial remnant of cytokinesis, the mammalian midbody (MB) is
released post-abscission inside large extracellular vesicles called MB remnants (MBRs) …

Every cell becomes two through a carefully orchestrated process of division. Prior to division,
contractile machinery must first be assembled at the cell midzone to ensure that the cut …

Multicellularity evolved multiple times in the history of life, with most reviewers agreeing that
it appeared at least 20 times in eukaryotes. However, a specific list of multicellular …

Cell proliferation is central to epithelial tissue development, repair, and homeostasis. During
cell division, small RhoGTPases control both actomyosin dynamics and cell-cell junction …

All animals evolved from a single lineage of unicellular precursors more than 600 million
years ago. Thus, the biological and genetic foundations for animal sensation, cognition and …

Embryo development depends upon maternally derived materials. Mammalian oocytes
undergo extreme asymmetric cytokinesis events, producing one large egg and two small …

The canonical eukaryotic cell cycle ends with cytokinesis, which physically divides the
mother cell in two and allows the cycle to resume in the newly individualized daughter cells …

Cell division involves separating the genetic material and cytoplasm of a mother cell into two
daughter cells. The last step of cell division, abscission, consists of cutting the cytoplasmic …