Gut microbiota in colorectal cancer development and therapy
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …
is its intimate association with the gut microbiota, which forms an essential part of the tumour …
[HTML][HTML] New frontiers in immune checkpoint B7-H3 (CD276) research and drug development
Abstract B7-H3 (CD276), a member of the B7 family of proteins, is a key player in cancer
progression. This immune checkpoint molecule is selectively expressed in both tumor cells …
progression. This immune checkpoint molecule is selectively expressed in both tumor cells …
[HTML][HTML] Crosstalk between gut microbiota and host immunity: impact on inflammation and immunotherapy
C Campbell, MR Kandalgaonkar, RM Golonka… - Biomedicines, 2023 - mdpi.com
Gut microbes and their metabolites are actively involved in the development and regulation
of host immunity, which can influence disease susceptibility. Herein, we review the most …
of host immunity, which can influence disease susceptibility. Herein, we review the most …
The microbial landscape of colorectal cancer
MT White, CL Sears - Nature Reviews Microbiology, 2024 - nature.com
Colorectal cancer (CRC) is a substantial source of global morbidity and mortality in dire
need of improved prevention and treatment strategies. As our understanding of CRC grows …
need of improved prevention and treatment strategies. As our understanding of CRC grows …
[HTML][HTML] The heightened importance of the microbiome in cancer immunotherapy
C Villemin, A Six, BA Neville, TD Lawley… - Trends in …, 2023 - cell.com
The human microbiome is recognized as a key factor in health and disease. This has been
further corroborated by identifying changes in microbiome composition and function as a …
further corroborated by identifying changes in microbiome composition and function as a …
Acetyltransferase from Akkermansia muciniphila blunts colorectal tumourigenesis by reprogramming tumour microenvironment
Objective The protein post-translational modification (PTM) in host cells can be rewritten by
bacterial enzymes and represents an unprecedented mechanism in the communication …
bacterial enzymes and represents an unprecedented mechanism in the communication …
[HTML][HTML] Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection
WJ Brewer, AM Xet-Mull, A Yu, MI Sweeney… - Cell reports, 2022 - cell.com
During mycobacterial infections, pathogenic mycobacteria manipulate both host immune
and stromal cells to establish and maintain a productive infection. In humans, non-human …
and stromal cells to establish and maintain a productive infection. In humans, non-human …
[HTML][HTML] Gut microbiota and tumor immune escape: A new perspective for improving tumor immunotherapy
Y He, J Huang, Q Li, W Xia, C Zhang, Z Liu, J Xiao, Z Yi… - Cancers, 2022 - mdpi.com
Simple Summary The gut microbiota is a commensal microbiota living in the human
intestine. Its status and composition have a profound impact on human antitumor immunity …
intestine. Its status and composition have a profound impact on human antitumor immunity …
B7-H3 regulates anti-tumor immunity and promotes tumor development in colorectal cancer
H Zhang, M Zhu, A Zhao, T Shi, Q Xi - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract and one
of the most common causes of cancer-related deaths worldwide. Immune checkpoint …
of the most common causes of cancer-related deaths worldwide. Immune checkpoint …
Mechanisms of metastatic colorectal cancer
Despite extensive research and improvements in understanding colorectal cancer (CRC), its
metastatic form continues to pose a substantial challenge, primarily owing to limited …
metastatic form continues to pose a substantial challenge, primarily owing to limited …