Sesquiterpenes and their derivatives-natural anticancer compounds: An update

T Abu-Izneid, A Rauf, MA Shariati, AA Khalil… - Pharmacological …, 2020 - Elsevier
Sesquiterpenes belong to the largest group of plant secondary metabolites, which consist of
three isoprene building units. These compounds are widely distributed in various …

[HTML][HTML] Application of sesquiterpene lactone: A new promising way for cancer therapy based on anticancer activity

A Aliarab, S Abroon, Y Rasmi, SGG Aziz - Biomedicine & …, 2018 - Elsevier
Cancer is one of the most dangerous diseases that are rapidly increasing globally. After
heart disease, it is the second leading cause of death, accounting for seven million deaths …

[HTML][HTML] MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3

Z Fan, H Cui, X Xu, Z Lin, X Zhang, L Kang, B Han… - Oncotarget, 2015 - ncbi.nlm.nih.gov
MiR-125a has been characterized as a tumor suppressor in several cancers. However, the
role of miR-125a in cervical cancer is unknown. In this study, we found the expression of …

Phenolic profiles, antioxidant, and antiproliferative activities of turmeric (Curcuma longa)

QQ Yang, LZ Cheng, T Zhang, S Yaron… - Industrial crops and …, 2020 - Elsevier
In this study, the phenolic profiles and bioactivities (antioxidant and antiproliferative
activities) of turmeric extracts obtained by ultrasound-assisted extraction (UAE) and …

Curcumin, demethoxycurcumin, and bisdemethoxycurcumin induced caspase-dependent and–independent apoptosis via Smad or Akt signaling pathways in HOS …

C Huang, HF Lu, YH Chen, JC Chen, WH Chou… - … medicine and therapies, 2020 - Springer
Background Osteosarcoma is the most common primary malignant bone tumor in children
and adolescents and has also been associated with a high degree of malignancy and …

A highly oxidized germacranolide from elephantopus tomentosus inhibits the growth of hepatocellular carcinoma cells by targeting EGFR in vitro and in vivo

Q Li, JQ Niu, JH Jia, W Xu, M Bai, GD Yao, SJ Song - Bioorganic Chemistry, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide,
with high mortality and poor prognosis. WBDC-1 is a novel highly oxidized germacranolide …

[HTML][HTML] Deoxyelephantopin induces reactive oxygen species-mediated apoptosis and autophagy in human osteosarcoma cells

J Zou, Y Zhang, J Sun, X Wang, H Tu, S Geng… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: Osteosarcoma is the predominant form of primary bone malignancy.
Although the combinational application of neoadjuvant chemotherapy and surgical resection …

Deoxyelephantopin induces apoptosis and enhances chemosensitivity of colon cancer via miR-205/bcl2 Axis

H Ji, K Zhang, G Pan, C Li, C Li, X Hu, L Yang… - International journal of …, 2022 - mdpi.com
Colon cancer (CC) is one of the major causes of cancer death in humans. Despite recent
advances in the management of CC, the prognosis is still poor and a new strategy for …

Fucoidan induces apoptosis and inhibits proliferation of hepatocellular carcinoma via the p38 MAPK/ERK and PI3K/Akt signal pathways

Y Duan, J Li, X Jing, X Ding, Y Yu… - Cancer Management and …, 2020 - Taylor & Francis
Purpose Fucoidan is a natural bioactive product with broad therapeutic applications.
Hepatocellular carcinoma (HCC) is a common malignancy of the liver associated with a …

Recent advances on cytotoxic sesquiterpene lactones

J Quintana, F Estévez - Current Pharmaceutical Design, 2018 - ingentaconnect.com
Sesquiterpene lactones are naturally occurring compounds that have attracted considerable
attention because to their vast array of biological activities. These plant-derived compounds …