The discoveries of nucleotide excision repair and transcription-coupled repair led by Phil
Hanawalt and a few colleagues sparked a dramatic evolution in our understanding of DNA …

Cellular metabolism constantly generates by‐products that are wasteful or even harmful.
Such compounds are excreted from the cell or are removed through hydrolysis to normal …

A novel automation pipeline for macromolecular structure solution by molecular replacement
is described. There is a special emphasis on the discovery and preparation of a large …

This paper describes a structure− activity study to identify novel, small-molecule inhibitors of
the enzyme deoxyuridine 5 '-triphosphate nucleotidohydrolase (dUTPase) from parasitic …

Artificially modified nucleotides, in the form of nucleoside analogues, are widely used in the
treatment of cancers and various other diseases, and have become important tools in the …

Structure-guided analysis of the new dimeric dUTPase family revealed its sequence
relationship to the phage T4 dCTPase, phosphoribosyl-ATP pyrophosphatase HisE, NTP …

The pseudorabies virus (PRV) causes severe and fatal acute respiratory disease in pigs.
During PRV proliferation, the enzyme deoxyuridine 5′-triphosphate nucleotide hydrolase …

ABSTRACT E165R, a highly specific dUTP nucleotidohydrolase (dUTPase) encoded by the
African swine fever virus (ASFV) genome, is required for productive replication of ASFV in …

Cyanophage S-2L is known to profoundly alter the biophysical properties of its DNA by
replacing all adenines (A) with 2-aminoadenines (Z), which still pair with thymines but with a …

The occurrence of modified bases in DNA is attributed to some major factors: incorporation
of altered nucleotide building blocks and chemical reactions or radiation effects on bases …