Harnessing genomic information for livestock improvement

M Georges, C Charlier, B Hayes - Nature Reviews Genetics, 2019 - nature.com
The world demand for animal-based food products is anticipated to increase by 70% by
2050. Meeting this demand in a way that has a minimal impact on the environment will …

1000 bull genomes project to map simple and complex genetic traits in cattle: applications and outcomes

BJ Hayes, HD Daetwyler - Annual review of animal biosciences, 2019 - annualreviews.org
The 1000 Bull Genomes Project is a collection of whole-genome sequences from 2,703
individuals capturing a significant proportion of the world's cattle diversity. So far, 84 million …

A comprehensive biomedical variant catalogue based on whole genome sequences of 582 dogs and eight wolves

V Jagannathan, C Drögemüller, T Leeb… - Animal …, 2019 - Wiley Online Library
The domestic dog serves as an excellent model to investigate the genetic basis of disease.
More than 400 heritable traits analogous to human diseases have been described in dogs …

Four novel candidate causal variants for deficient homozygous haplotypes in Holstein cattle

IM Häfliger, M Spengeler, FR Seefried… - Scientific reports, 2022 - nature.com
Mendelian variants can determine both insemination success and neonatal survival and
thus influence fertility and rearing success of cattle. We present 24 deficient homozygous …

[HTML][HTML] A splice site mutation in CENPU is associated with recessive embryonic lethality in Holstein cattle

C Hozé, C Escouflaire, M Mesbah-Uddin, A Barbat… - Journal of Dairy …, 2020 - Elsevier
ABSTRACT A genome scan for homozygous haplotype deficiency coupled with whole-
genome sequence data analysis is a very effective method to identify embryonic lethal …

Identification of candidate lethal haplotypes and genomic association with post-natal mortality and reproductive traits in Nellore cattle

PI Schmidt, LFM Mota, LFS Fonseca… - Scientific Reports, 2023 - nature.com
The wide use of genomic information has enabled the identification of lethal recessive
alleles that are the major genetic causes of reduced conception rates, longer calving …

Identification of homozygous haplotypes carrying putative recessive lethal mutations that compromise fertility traits in French Lacaune dairy sheep

M Ben Braiek, S Fabre, C Hozé, JM Astruc… - Genetics Selection …, 2021 - Springer
Background Homozygous recessive deleterious mutations can cause embryo/fetal or
neonatal lethality, or genetic defects that affect female fertility and animal welfare. In …

[HTML][HTML] Selected Monogenic Genetic Diseases in Holstein Cattle—A Review

M Gozdek, S Mucha, A Prostek, T Sadkowski - Genes, 2024 - mdpi.com
Genetic disorders arise from alterations in the hereditary information encoded in DNA,
leading to potential detrimental effects on the well-being and vitality of organisms. Within the …

[HTML][HTML] Mating allocations in Holstein combining genomic information and linear programming optimization at the herd level

C Bengtsson, H Stålhammar, JR Thomasen… - Journal of Dairy …, 2023 - Elsevier
In this study, we explored mating allocation in Holstein using genomic information for 24,333
Holstein females born in Denmark, Finland, and Sweden. We used 2 data sets of bulls: the …

[HTML][HTML] A missense mutation (p. Tyr452Cys) in the CAD gene compromises reproductive success in French Normande cattle

M Mesbah-Uddin, C Hoze, P Michot, A Barbat… - Journal of dairy …, 2019 - Elsevier
We scanned the genome of 77,815 Normande cattle with different Illumina SNP chips
(Illumina Inc., San Diego, CA) to map recessive embryonic lethal mutations using …