Lysosomes and lysosomal cathepsins in cell death

U Repnik, V Stoka, V Turk, B Turk - … et Biophysica Acta (BBA)-Proteins and …, 2012 - Elsevier
Lysosomes are the key degradative compartments of the cell. Lysosomal cathepsins, which
are enclosed in the lysosomes, help to maintain the homeostasis of the cell's metabolism by …

Heparan sulfate and heparan sulfate proteoglycans in cancer initiation and progression

A Nagarajan, P Malvi, N Wajapeyee - Frontiers in endocrinology, 2018 - frontiersin.org
Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily
modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains …

Lysosomal–mitochondrial cross-talk during cell death

U Repnik, B Turk - Mitochondrion, 2010 - Elsevier
Lysosomes are membrane-bound organelles, which contain an arsenal of different
hydrolases, enabling them to act as the terminal degradative compartment of the …

The endolysosomal system in cell death and survival

U Repnik, MH Česen, B Turk - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
The endocytic pathway is a system specialized for the uptake of compounds from the cell
microenvironment for their degradation. It contains an arsenal of hydrolases, including …

RGTA® or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients

D Barritault, M Gilbert-Sirieix, KL Rice, F Siñeriz… - Glycoconjugate …, 2017 - Springer
The importance of extracellular matrix (ECM) integrity in maintaining normal tissue function
is highlighted by numerous pathologies and situations of acute and chronic injury …

Repair effects of astragalus polysaccharides with different molecular weights on oxidatively damaged HK-2 cells

J Han, D Guo, XY Sun, JM Wang, JM Ouyang… - Scientific Reports, 2019 - nature.com
This study investigated the repair effects of three Astragalus polysaccharides (APSs) with
different molecular weights (Mws) on injured human renal proximal tubular epithelial (HK-2) …

New roles of glycosaminoglycans in α-synuclein aggregation in a cellular model of Parkinson disease

S Lehri-Boufala, MO Ouidja, V Barbier-Chassefière… - PloS one, 2015 - journals.plos.org
The causes of Parkinson disease (PD) remain mysterious, although some evidence
supports mitochondrial dysfunctions and α-synuclein accumulation in Lewy bodies as major …

Mitochondrial proteomic analysis of cisplatin resistance in ovarian cancer

NP Chappell, P Teng, BL Hood, G Wang… - Journal of proteome …, 2012 - ACS Publications
Epithelial ovarian cancer (EOC) is the leading cause of death among women with
gynecologic malignancies and accounts for approximately 6% of cancer deaths among …

In vitro anti-inflammatory effects of hyaluronic acid in ethanol-induced damage in skin cells

MG Neuman, RM Nanau… - Journal of pharmacy …, 2011 - journals.library.ualberta.ca
Ethyl alcohol (ethanol) is commonly applied in cosmetic and pharmaceutical preparations,
as well as disinfectant for chronic wounds. Objective: The present study aimed to appraise …

Glycosaminoglycan and proteoglycan biotherapeutics in articular cartilage protection and repair strategies: novel approaches to visco‐supplementation in …

AJ Hayes, J Melrose - Advanced Therapeutics, 2019 - Wiley Online Library
The aim of this study is to review developments in glycosaminoglycan and proteoglycan
research relevant to cartilage repair biology and in particular the treatment of osteoarthritis …