The molecules of today—the medicines that cure diseases, the agrochemicals that protect
our crops, the materials that make life convenient—are becoming increasingly sophisticated …

Automation has become an increasingly popular tool for synthetic chemists over the past
decade. Recent advances in robotics and computer science have led to the emergence of …

High-throughput experimentation (HTE) has revolutionized the pharmaceutical industry,
most notably allowing for rapid screening of compound libraries against therapeutic targets …

Conspectus The structural complexity of pharmaceuticals presents a significant challenge to
modern catalysis. Many published methods that work well on simple substrates often fail …

The amount of chemical synthesis literature is growing quickly; however, it takes a long time
to share and evaluate new processes among laboratories. Here we present an approach …

The Catalysis Laboratory at Merck was established in 2002 to discover and develop
asymmetric hydrogenation transformations for application to the company's pipeline. Twenty …

Exploration of synthetic transformations using high throughput experimentation (HTE) can
accelerate the rapid discovery of optimal conditions for organic reactions and improve our …

Aromatic C–H functionalization reactions are an important part of the synthetic chemistry
toolbox. Accurate prediction of site selectivity can be crucial for prioritizing target compounds …

Automated kinetic profiling is a valuable tool for providing insights into key mechanistic
features of complex catalytic systems. In an attempt to optimize a palladium-catalyzed …

Traditionally, new synthetic reactions have been developed using a model substrate to
screen reaction conditions before testing the optimized conditions with a range of more …