Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

The control of inflammation is strictly regulated to ensure the adequate intensity and duration
of an inflammatory response, enabling the removal of the trigger factors and the restoration …

Biomaterial wound dressings, such as hydrogels, interact with host cells to regulate tissue
repair. This study investigates how crosslinking of gelatin-based hydrogels influences …

Purpose: Phosphatase and tensin homolog (PTEN) loss of function occurs in approximately
50% of patients with metastatic castrate-resistant prostate cancer (mCRPC), and is …

Neutrophils are polymorphonuclear leukocytes that play a central role in host defense
against infection and tissue injury. They are rapidly recruited to the inflamed site and …

PTX3 is a soluble pattern recognition molecule (PRM) belonging to the humoral innate
immune system, rapidly produced at inflammatory sites by phagocytes and stromal cells in …

Idiopathic pulmonary fibrosis (IPF) is the most severe form of chronic lung fibrosis.
Circulating monocytes have been implicated in immune pathology in IPF but their phenotype …

Inflammation is a fundamental physiological response orchestrated by innate immune cells
to restore tissue homeostasis. Specialized pro-resolving mediators (SPMs) are involved in …

RELMα is a small, secreted protein expressed by type 2 cytokine-activated “M2”
macrophages in helminth infection and allergy. At steady state and in response to type 2 …

Due to their broad functional plasticity, myeloid cells contribute to both liver injury and
recovery during acetaminophen overdose-induced acute liver injury (APAP-ALI). A …