Biological hypotheses and biomarkers of bipolar disorder
E Sigitova, Z Fišar, J Hroudová… - Psychiatry and …, 2017 - Wiley Online Library
The most common mood disorders are major depressive disorders and bipolar disorders
(BD). The pathophysiology of BD is complex, multifactorial, and not fully understood …
(BD). The pathophysiology of BD is complex, multifactorial, and not fully understood …
The FKBP51 glucocorticoid receptor co-chaperone: regulation, function, and implications in health and disease
Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR),
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
Sex differences: Transcriptional signatures of stress exposure in male and female brains
More than two‐thirds of patients suffering from stress‐related disorders are women but over
two‐thirds of suicide completers are men. These are just some examples of the many sex …
two‐thirds of suicide completers are men. These are just some examples of the many sex …
Hsp90 and FKBP51: complex regulators of psychiatric diseases
M Criado-Marrero, T Rein… - … of the Royal …, 2018 - royalsocietypublishing.org
Mood disorders affect nearly a quarter of the world's population. Therefore, understanding
the molecular mechanisms underlying these conditions is of great importance. FK-506 …
the molecular mechanisms underlying these conditions is of great importance. FK-506 …
[HTML][HTML] Transcriptomic evidence for alterations in astrocytes and parvalbumin interneurons in subjects with bipolar disorder and schizophrenia
Background High-throughput expression analyses of postmortem brain tissue have been
widely used to study bipolar disorder and schizophrenia. However, despite the extensive …
widely used to study bipolar disorder and schizophrenia. However, despite the extensive …
Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex
Identification and characterisation of novel targets for treatment is a priority in the field of
psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a …
psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a …
Commonality in dysregulated expression of gene sets in cortical brains of individuals with autism, schizophrenia, and bipolar disorder
Individuals affected with different neuropsychiatric disorders such as autism (AUT),
schizophrenia (SCZ) and bipolar disorder (BPD), may share similar clinical manifestations …
schizophrenia (SCZ) and bipolar disorder (BPD), may share similar clinical manifestations …
Microarray profiling and co-expression network analysis of circulating lncRNAs and mRNAs associated with major depressive disorder
Z Liu, X Li, N Sun, Y Xu, Y Meng, C Yang, Y Wang… - PloS one, 2014 - journals.plos.org
LncRNAs, which represent one of the most highly expressed classes of ncRNAs in the brain,
are becoming increasingly interesting with regard to brain functions and disorders. However …
are becoming increasingly interesting with regard to brain functions and disorders. However …
Transcriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophrenia
The application of microarray technology in schizophrenia research was heralded as
paradigm-shifting, as it allowed for high-throughput assessment of cell and tissue function …
paradigm-shifting, as it allowed for high-throughput assessment of cell and tissue function …
Hypothesis of the neuroendocrine cortisol pathway gene role in the comorbidity of depression, type 2 diabetes, and metabolic syndrome
C Gragnoli - The application of clinical genetics, 2014 - Taylor & Francis
Depression, type 2 diabetes (T2D), and metabolic syndrome (MetS) are often comorbid.
Depression per se increases the risk for T2D by 60%. This risk is not accounted for by the …
Depression per se increases the risk for T2D by 60%. This risk is not accounted for by the …