This review summarizes our current understanding of translation in prokaryotes, focusing on
the mechanistic and structural aspects of each phase of translation: initiation, elongation …

Mitochondria are essential organelles of endosymbiotic origin that are responsible for
oxidative phosphorylation within eukaryotic cells. Independent evolution between species …

The dynamic ribosome–translocon complex, which resides at the endoplasmic reticulum
(ER) membrane, produces a major fraction of the human proteome,. It governs the synthesis …

Ribosomes catalyze protein synthesis by cycling through various functional states. These
states have been extensively characterized in vitro, but their distribution in actively …

Ribosomes are translational machineries that catalyse protein synthesis. Ribosome
structures from various species are known at the atomic level, but obtaining the structure of …

Macromolecular complexes are intrinsically flexible and often challenging to purify for
structure determination by single-particle cryo-electron microscopy (cryo-EM). Such …

INTRODUCTION The tightly controlled process of gene expression requires messenger
RNAs (mRNAs), which represent DNA-derived blueprints for polypeptides, to be translated …

Mammalian mitochondrial ribosomes (mitoribosomes) synthesize mitochondrially encoded
membrane proteins that are critical for mitochondrial function. Here we present the complete …

We describe an integrated workflow that robustly identifies cross-links from endogenous
protein complexes in human cellular lysates. Our approach is based on the application of …

The highly divergent ribosomes of human mitochondria (mitoribosomes) synthesize 13
essential proteins of oxidative phosphorylation complexes. We have determined the …