Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria
H Liu, Z Hu, M Li, Y Yang, S Lu, X Rao - Journal of biomedical science, 2023 - Springer
Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …
community medical resources. As a result of the increasing prevalence of multidrug-resistant …
Phage-encoded endolysins
F Abdelrahman, M Easwaran, OI Daramola, S Ragab… - Antibiotics, 2021 - mdpi.com
Due to the global emergence of antibiotic resistance, there has been an increase in
research surrounding endolysins as an alternative therapeutic. Endolysins are phage …
research surrounding endolysins as an alternative therapeutic. Endolysins are phage …
Recombinant endolysins as potential therapeutics against antibiotic-resistant Staphylococcus aureus: current status of research and novel delivery strategies
H Haddad Kashani, M Schmelcher… - Clinical microbiology …, 2018 - Am Soc Microbiol
Staphylococcus aureus is one of the most common pathogens of humans and animals,
where it frequently colonizes skin and mucosal membranes. It is of major clinical importance …
where it frequently colonizes skin and mucosal membranes. It is of major clinical importance …
Applications of bacteriophages versus phage enzymes to combat and cure bacterial infections: an ambitious and also a realistic application?
B Maciejewska, T Olszak, Z Drulis-Kawa - Applied microbiology and …, 2018 - Springer
Bacteriophages (phages) are viruses that infect bacteria. The “predator–prey” interactions
are recognized as a potentially effective way to treat infections. Phages, as well as phage …
are recognized as a potentially effective way to treat infections. Phages, as well as phage …
Endolysins as emerging alternative therapeutic agents to counter drug-resistant infections
Endolysins are the lytic products of bacteriophages which play a specific role in the release
of phage progeny by degrading the peptidoglycan of the host bacterium. In the light of …
of phage progeny by degrading the peptidoglycan of the host bacterium. In the light of …
Synthetic biology of modular endolysins
H Gerstmans, B Criel, Y Briers - Biotechnology advances, 2018 - Elsevier
Endolysins and their derivatives have emerged in recent years as a novel class of
antibacterials, which have now entered the clinical phases. Their rapid mode-of-action and …
antibacterials, which have now entered the clinical phases. Their rapid mode-of-action and …
Phage-derived peptidoglycan degrading enzymes: challenges and future prospects for in vivo therapy
Peptidoglycan degrading enzymes are of increasing interest as antibacterial agents,
especially against multi-drug resistant pathogens. Herein we present a review about the …
especially against multi-drug resistant pathogens. Herein we present a review about the …
Enzybiotics: Enzyme-based antibacterials as therapeutics
D Dams, Y Briers - Therapeutic enzymes: Function and clinical …, 2019 - Springer
Antibiotics have saved millions of lives. However, the overuse and misuse of antibiotics have
contributed to a rapid emergence of antibiotic resistance worldwide. In addition, there is an …
contributed to a rapid emergence of antibiotic resistance worldwide. In addition, there is an …
Phage lysins for fighting bacterial respiratory infections: a new generation of antimicrobials
Lower respiratory tract infections and tuberculosis are responsible for the death of about 4.5
million people each year and are the main causes of mortality in children under 5 years of …
million people each year and are the main causes of mortality in children under 5 years of …
[HTML][HTML] Bacteriophage-encoded enzymes destroying bacterial cell membranes and walls, and their potential use as antimicrobial agents
Ł Grabowski, K Łepek, M Stasiłojć… - Microbiological …, 2021 - Elsevier
Appearance of pathogenic bacteria resistant to most, if not all, known antibiotics is currently
one of the most significant medical problems. Therefore, development of novel antibacterial …
one of the most significant medical problems. Therefore, development of novel antibacterial …