The translation of biological glycosylation in humans to the clinical applications involves
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …

Glycosylation can be a critical quality attribute in biologic manufacturing. In particular, it has
implications on the half‐life, immunogenicity, and pharmacokinetics of therapeutic …

Monoclonal antibodies (mAbs) are currently the largest and fastest growing class of
biopharmaceuticals, and they address unmet medical needs, eg, in oncology and in auto …

Until recently, glycosidases, naturally hydrolyzing carbohydrate-active enzymes, have found
few synthetic applications in industry, being primarily used for cleaving unwanted …

The milk glycobiome has a significant impact on the gut microbiota of infants, which plays a
pivotal role in health and development. Fucosylated human milk oligosaccharides (HMOs) …

Monoclonal antibodies (mAbs) have been developed as therapeutics, especially for the
treatment of cancer, inflammation, and infectious diseases. Because the glycosylation of …

Non–small cell lung cancer (NSCLC), a major life-threatening disease accounting for 85% of
all lung cancer cases, has been treated with tyrosine kinase inhibitors (TKIs), but often …

Fucosylation is important for the function of many proteins with biotechnical and medical
applications. Alpha-fucosidases comprise a large enzyme family that recognizes fucosylated …

The gastrointestinal microbiota members produce α-l-fucosidases that play key roles in
mucosal, human milk, and dietary oligosaccharide assimilation. Here, 36 open reading …

The maternal milk glycobiome is crucial for shaping the gut microbiota of infants. Although
high core fucosylation catalyzed by fucosyltransferase 8 (Fut8) is a general feature of human …