Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …

The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …

Despite several decades of intense research focused on understanding function (s) and
disease-associated malfunction of p53, there is no sign of any “mid-life crisis” in this rapidly …

Although ribosomal proteins are known for playing an essential role in ribosome assembly
and protein translation, their ribosome-independent functions have also been greatly …

Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place
in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its …

The nucleolus is a prominent subnuclear compartment, where ribosome biosynthesis takes
place. Recently, the nucleolus has gained attention for its novel role in the regulation of …

The nucleolus is the major site for synthesis of ribosomes, complex molecular machines that
are responsible for protein synthesis. A wealth of research over the past 20 years has clearly …

The traditional view of p53 activation includes three steps—p53 stabilization, DNA binding,
and transcriptional activation. However, recent studies indicate that each step of p53 …

MYC regulates the transcription of thousands of genes required to coordinate a range of
cellular processes, including those essential for proliferation, growth, differentiation …

Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …