Excessive abnormal angiogenesis plays a pivotal role in tumor progression and is a
hallmark of solid tumors. This process is driven by an imbalance between pro-and anti …

Drug repurposing or repositioning has been well-known to refer to the therapeutic
applications of a drug for another indication other than it was originally approved for …

Over the past decades curcuminoids have been extensively studied for their biological
activities such as antiulcer, antifibrotic, antiviral, antibacterial, antiprotozoal, antimutagenic …

Multidrug resistance (MDR) is a major obstacle in the therapy of infectious diseases and
cancer. One of the major mechanisms of MDR is the overexpression of efflux pumps (EPs) …

The quinoline molecule is a chemical motif showing a highly promising pharmacological
potential. Its numerous derivatives introduced into medicine revolutionized in the treatment …

Glioblastoma (GBM) is the most aggressive glial tumor of the central nervous system.
Despite intense scientific efforts, patients diagnosed with GBM and treated with the current …

Background and Purpose: Drug repositioning is a promising strategy for discovering new
therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their …

Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …

Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome (SARS) in
humans that is caused by SARS-associated coronavirus type 2 (SARS-CoV-2). In the …

While majority of the current treatment approaches for cancer remain expensive and are
associated with several side effects, development of new treatment modalities takes a …